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Control of gene expression during lymphoid development: targeted gene disruption provides new clues
Author(s) -
DOOIJES DENNIS,
CLEVERS HANS
Publication year - 1997
Publication title -
apmis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0903-4641
DOI - 10.1111/j.1699-0463.1997.tb00579.x
Subject(s) - biology , gene , gene expression , regulation of gene expression , transcription factor , lineage (genetic) , genetics , cell lineage , cellular differentiation
The expression of structural genes is thought to be regulated by DNA‐binding factors interacting with cis‐acting regulatory elements. These regulatory elements, identified for many lymphopoietic genes, have served in recent years to identify and clone novel transcription factors. The expression of some of these factors is found to be confined to the lymphoid lineage. This regulated expression in both time and space is thought to mediate entry into and progression along the correct developmental differentiation programs. In recent years, many laboratories have tried to assess the functional relevance of these DNA‐binding factors by making use of gene targeting techniques. A review of the results of such knock‐out experiments and the consequences for lymphoid development models appears below.