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Mast cell and mast cell granule phenotypes in normal and Nippostrongylus‐infected rats
Author(s) -
KRÜGER P. G.,
HUNTLEY J. F.,
MacKELLAR A.,
RØLI J.,
NEWLANDS G. F. J.
Publication year - 1997
Publication title -
apmis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0903-4641
DOI - 10.1111/j.1699-0463.1997.tb00563.x
Subject(s) - nippostrongylus brasiliensis , mast cell , granule (geology) , mast (botany) , phenotype , immunology , cell , biology , microbiology and biotechnology , helminths , genetics , gene , paleontology
In the rat, the individual mast cell secretory granules may be divided into three subpopulations based on the presence of the specific proteases RMCP‐1, RMCP‐2, or a variable combination of these two proteases. Mast cells in the tongue only express RMCP‐1, both in normal and infected animals, whereas in the other tissue locations studied (lung, intestinal mucosa and submucosa, tracheal epithelium and submucosa) the mast cells contain all three granule subtypes in a wide variation of combinations. These studies demonstrate that there is wide heterogeneity in protease expression in rat mast cells, which may be influenced by local stimulation with environmental tissue factors.