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Antigenic determinants in type 1 diabetes mellitus:
Author(s) -
Dotta F.,
Mario U.
Publication year - 1996
Publication title -
apmis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0903-4641
DOI - 10.1111/j.1699-0463.1996.tb04941.x
Subject(s) - autoantibody , autoimmunity , immunology , type 1 diabetes , diabetes mellitus , disease , antigen , autoimmune disease , nod , medicine , pancreatic islets , nod mice , antibody , biology , islet , endocrinology
Type 1 diabetes mellitus (IDDM) is a disease caused by the autoimmune destruction of insulin‐producing pancreatic ß cells that takes place in genetically predisposed individuals. The results of the studies performed so far during the search for “the target antigen” in ß cell autoimmunity have indicated that, unlike many autoimmune disorders, type 1 diabetes appears to be the result of an autoimmune response to a multiplicity of autoantigens. Autoantibodies and autoreactive T lymphocytes reacting with islet target molecules of protein or glycolipid nature have been shown in the circulation of individuals and of animal models of type 1 diabetes (NOD mouse and BB rat) before and at the onset of the disease. In the present article we have reviewed the data available on the antigenic determinants in type 1 diabetes, with particular reference to those recognized by autoantibodies which represent the best available predictive marker of future disease development in large scale screening studies.