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Synergistic effect of ethyl‐6‐O‐decanoyl glucoside and chlorhexidine in contact lens disinfection
Author(s) -
Lehtonen OlliPekka J.,
VaahtorantaLehtonen Hanna,
Leivo Pekka,
MÄKi Mirja
Publication year - 1996
Publication title -
apmis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0903-4641
DOI - 10.1111/j.1699-0463.1996.tb04918.x
Subject(s) - chlorhexidine , biguanide , chemistry , serratia marcescens , contact lens , pseudomonas aeruginosa , microbiology and biotechnology , ethyl acetate , chlorhexidine gluconate , pharmacology , medicine , bacteria , chromatography , ophthalmology , biochemistry , dentistry , diabetes mellitus , escherichia coli , biology , genetics , metformin , gene , endocrinology
Contact lenses with adherent Serratia marcescens and Pseudomonas aeruginosa could not be sterilised either with polyaminopropyl biguanide or with chlorhexidine (CHX) commercial solutions meant for contact lens disinfection, even after treatment lasting 12 h. Ethyl‐6‐O‐decanoyl glucoside (EDG) with chlorhexidine enhanced the killing significantly. The same was also found to be the case for dispersed cells of P. aeruginosa on cellulose acetate filters. EDG enhances the bactericidal effect of 0.00025 CHX by a mechanism not solely due to detergent action and is a potential adjunct to CHX in clinical applications.