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Antibiotic resistance mechanisms in Salmonella species causing bacteraemia in Malawi and Kenya
Author(s) -
LEEGAARD T. M.,
GESTEL M. H.,
PETIT P. L. C.,
KLUNDERT J. A. M.
Publication year - 1996
Publication title -
apmis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0903-4641
DOI - 10.1111/j.1699-0463.1996.tb00721.x
Subject(s) - salmonella , amoxicillin , clavulanic acid , microbiology and biotechnology , antibiotics , biology , salmonella enteritidis , drug resistance , bacteria , genetics
In two studies on the causative agents of bacteraemia in Malawi and Kenya, 33 Salmonella strains were isolated. Fourteen strains of Salmonella typhimurium and Salmonella enteritidis were found to exhibit resistance to amoxicillin, amoxicillin/clavulanic acid and cotrimoxazole as well as decreased susceptibility to a range of aminoglycosides. The resistant strains were studied to establish their resistance mechanisms. Beta‐lactamase co‐focusing with TEM‐1 was present in 12 strains. In two strains, both S. typhimurium from Kenya, an OXA‐1 beta‐lactamase was detected. The aminoglycoside‐modifying enzyme ANT(2“) was found in 10 strains. The presence of the encoding genes was confirmed by PCR. For comparison, susceptibility records of 73 Salmonella strains isolated during the past 14 years in our hospital were studied retrospectively. Only one of these strains was resistant to amoxicillin. This resistance was acquired during therapy.