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Up‐regulation of CD44 and ICAM‐1 expression on gastric epithelial cells by H. pylori
Author(s) -
FAN XUE G.,
FAN XUE J.,
XIA HUAXIANG,
KEELING PAUL W. N.,
KELLEHER DERMOT
Publication year - 1995
Publication title -
apmis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0903-4641
DOI - 10.1111/j.1699-0463.1995.tb01432.x
Subject(s) - helicobacter pylori , cell adhesion molecule , cd44 , peripheral blood mononuclear cell , inflammation , cytokine , gastric mucosa , biology , cell adhesion , in vitro , immunology , chemistry , microbiology and biotechnology , cell , stomach , biochemistry , genetics
Interaction between lymphocytes and epithelial cells may play a key role in Helicobacter pylori (H. pylori) ‐associated gastric mucosal inflammation. This interaction process is at least partially mediated by various cell adhesion molecules. The aims of the present study were to assess using flow cytometric analysis whether H. pylori directly or supernatants from H. pylori ‐activated peripheral blood mononuclear cells (PBMC) can affect the expression of adhesion molecules on the gastric epithelial cell line AGS in vitro . The results showed that resting AGS cells expressed CD44 and ICAM‐1. Co‐culture of AGS with H. pylori or cytokine‐rich supernatants from H. pylori ‐activated PBMC resulted in up‐regulation of expression of CD44 and ICAM‐1 on AGS cells. These data suggest that H. pylori directly and indirectly through inflammatory cytokines may contribute to alternations in adhesion molecule expression on gastric epithelial cells. This may be of pathological significance in H. pylori ‐associated gastric mucosal inflammation and carcinogenesis.