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Relationship between the cell surface hydrophobicity and adherence of Candida krusei and Candida albicans to epithelial and denture acrylic surfaces
Author(s) -
SAMARANAYAKE Y. H.,
WU P. C.,
SAMARANAYAKE L. P.,
SO M.
Publication year - 1995
Publication title -
apmis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0903-4641
DOI - 10.1111/j.1699-0463.1995.tb01427.x
Subject(s) - candida krusei , candida albicans , microbiology and biotechnology , corpus albicans , adhesion , virulence , cell , yeast , cell adhesion , chemistry , biology , biochemistry , organic chemistry , gene
C. krusei is an emerging pathogen, especially in immunocompromised hosts, and is implicated, together with Candida albicans , as an etiological agent of oral candidoses. As the cell surface hydrophobicity of these yeasts appears to be important in the pathogenesis of superficial candidoses, 20 oral isolates of C. krusei and 5 oral isolates of C. albicans were investigated using a biphasic (hydrocarbon/aqueous) separation hydrophobicity assay. All the C. krusei isolates demonstrated significantly greater hydrophobicity than the C. albicans isolates (p<0.001). Further, there were significant intra‐species differences in cell surface hydrophobicity amongst C. krusei isolates. When hydrophobicity and adhesion to surfaces were compared using data from a previous study, there was a positive correlation between the cell surface hydrophobicity and adhesion of C. krusei isolates to HeLa surfaces (r=0.53, p<0.05), but not to acrylic surfaces. The current data, while confirming the inter‐ and intraspecies differences in cell surface hydrophobicity of Candida species , indicate that this attribute together with other cell surface features may determine the hierarchy of virulence amongst the different Candida species.