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Expression of the intercellular adhesion molecule‐3 (ICAM‐3) in human renal tissue with relation to kidney transplants and various inflammatory diseases
Author(s) -
KNUDSEN H.,
ANDERSEN C. B.,
LADEFOGED S. D.
Publication year - 1995
Publication title -
apmis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0903-4641
DOI - 10.1111/j.1699-0463.1995.tb01411.x
Subject(s) - intercellular adhesion molecule 1 , glomerulonephritis , icam 1 , kidney , cell adhesion molecule , immune system , nephritis , inflammation , immunology , lymphocyte function associated antigen 1 , intercellular adhesion molecule , immunohistochemistry , medicine , antigen , nephropathy , pathology , cell adhesion , biology , cell , endocrinology , diabetes mellitus , genetics
Adhesion molecules are important for immune regulatory mechanisms concerning antigen presentation, lymphocyte activation, localisation and migration as well as effector‐target cell interactions in inflammatory processes. The immunohistochemical expression of ICAM‐3, a recently cloned new member of the immunoglobulin family which also binds leucocyte function antigen 1 (LFA‐1), was examined in 80 needle core biopsies from 35 renal allografts, 7 patients with mesangioproliferative glomerulonephritis, 5 patients with extracapillary glomerulonephritis, 4 patients with interstitial nephritis and 5 patients with diabetic nephropathy and 20 normal kidneys. In all types of lesions ICAM‐3 was constitutively expressed on the majority of infiltrating leucocytes without detectable upregulation or presentation on possible target structures during inflammation indicating its possible role to be mainly in initiation of the inflammatory response.