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HLA antigens in ulcerative colitis and primary sclerosing cholangitis
Author(s) -
LEIDENIUS MARJUT H. K.,
KOSKIMIES SAIJA A.,
KELLOKUMPU ILMO H.,
HÖCKERSTEDT KRISTER A. V.
Publication year - 1995
Publication title -
apmis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0903-4641
DOI - 10.1111/j.1699-0463.1995.tb01400.x
Subject(s) - primary sclerosing cholangitis , ulcerative colitis , medicine , human leukocyte antigen , colitis , gastroenterology , immunology , hla b , allele , antigen , disease , biology , gene , biochemistry
The aims of this study were to find out whether the alleles of the HLA class I or II region are associated with susceptibility to ulcerative colitis, and to show whether there is a difference or similarity in HLA associations between primary sclerosing cholangitis and ulcerative colitis. HLA‐A, B, C and DR antigens were studied using the standard lymphocyte microcytotoxicity test in 24 Finnish patients with primary sclerosing cholangitis, 77 patients with ulcerative colitis, and 106 controls. HLA‐B8 (54%) and DR3 (60%) were associated with primary sclerosing cholangitis. HLA‐DR1 (46%) and DR6 (20%) seemed more common in ulcerative colitis than in controls. A positive association with Cw7 was common to both ulcerative colitis (25%) and primary sclerosing cholangitis (33%). Our results indicate that ulcerative colitis is more heterogeneous than primary sclerosing cholangitis in its HLA‐DR associations.