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Shigella flexneri adherence to and multiplication in coxsackie B1 virus‐infected HEp‐2 cells
Author(s) -
Modalsli KRISTIN R.,
Bukholm GEIR,
HolbergPetersen MONA,
DegrÉ MIKLOS
Publication year - 1995
Publication title -
apmis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0903-4641
DOI - 10.1111/j.1699-0463.1995.tb01103.x
Subject(s) - shigella flexneri , virology , virulence , virus , biology , microbiology and biotechnology , shigella , plasmid , intracellular , in vitro , salmonella , gene , bacteria , escherichia coli , genetics
Coxsackie B1 virus infection enhances the susceptibility of in vitro cultured HEp‐2 cells to invasiveness by Shigella flexneri. We have studied the effect of viral infection on two phases of the invasiveness. Only a minor part was mediated by enhanced bacterial adherence to the cells, and the intracellular multiplication was unaffected by the virus. Enhanced adherence was not dependent on the presence of the gene product of the 140 Md virulence associated plasmid. Our data indicate that enhanced invasiveness induced by viral infection is mediated by an effect on other phases of the invasiveness.