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The modulation of tumour necrosis factor‐α, interleukin‐1α and glucose levels with GMDP and other analogues of muramyl dipeptide
Author(s) -
Adeleye T. A.,
Moreno C.,
Ivanyi J.,
Aston R.
Publication year - 1994
Publication title -
apmis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0903-4641
DOI - 10.1111/j.1699-0463.1994.tb04859.x
Subject(s) - muramyl dipeptide , lipopolysaccharide , tumor necrosis factor alpha , cytokine , pharmacology , interleukin , medicine , corynebacterium parvum , immunology , immune system
Immunomodulatory agent muramyl dipeptide (MDP) and seven of its analogues were tested for ability to counteract the toxic actions of lipopolysaccharide (LPS) in experimental mouse models. Female BALB/c mice were presensitized with Corynebacterium parvum (P. acnes) and given MDP or equimolar doses of one of its analogues after 2 weeks, followed by intravenous challenge with LPS 18 h later. This treatment produced a sharp increase in blood cytokine (TNF‐oc, IL‐la) levels 4 h after LPS administration followed by a decline to control values after 6 h. Four analogues, GMDP, threonylMDP, GMDPBenz and GMDPOBut, were able to reduce the level of cytokines induced with LPS. For most of the analogues, the higher doses reduced the levels of TNF‐a but slightly increased the concomitant IL‐lα levels. GMDP was the most effective compound tested in terms of reduction of TNF‐α and IL‐lα levels, as well as for reduction of the hypoglycaemia caused by the administration of LPS.