Serine‐stretch protein (SERP) of Plasmodium falciparum corresponds to the exoantigen Ag2, a target of antibodies associated with protection against malaria

A mixture of Plasmodium falciparum exoantigens inducing lymphocyte activation and cytokine production was shown to contain the malaria vaccine candidate, the serine‐stretch protein. This protein was shown serologically to correspond to Ag2, an exoantigen recognized by antibodies linked with protection against malaria. The glycophorin‐binding protein, the histidine‐rich protein II, the S‐antigen, the heat shock protein 70, the ring‐infected erythrocyte surface antigen, and the apical membrane antigen‐1 were also shown serologically to be present in the mixture of exoantigens.