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Depletion of Langerhans cells in cervical HPV infection is associated with replication of the virus
Author(s) -
LEHTINEN MATTI,
RANTALA IMMO,
TOIVONEN ANNE,
LUOTO HARRI,
AINE RISTO,
LAUSLAHTI KALEVI,
YLÄOUTINEN ARI,
ROMPPANEN URSULA,
PAAVONEN JORMA
Publication year - 1993
Publication title -
apmis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0903-4641
DOI - 10.1111/j.1699-0463.1993.tb00188.x
Subject(s) - langerhans cell , antibody , biology , virus , in situ hybridization , epithelium , virology , human papillomavirus , hpv infection , dna , immunology , antigen , gene , cervical cancer , medicine , gene expression , genetics , cancer
We studied the quantity of Langerhans cells in 36 patients with cervical human papillomavirus (HPV) infection. Significantly fewer Langerhans cells (p<0.05) were found in patients with compared to those without DNA tetraploidy. Similarly, patients positive for HPV 16/18 DNA by in situ hybridization or antipeptide IgA antibodies to HPV 18 tended to have fewer Langerhans cells than those negative for HPV 16/18 DNA or IgA antibodies. Our results suggest that depletion of Langerhans cells is associated with productive HPV 16/18 infection in the cervical epithelium.