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Antimycobacterial activity of methdilazine (Md), an antimicrobic phenothiazine
Author(s) -
CHAKRABARTY A. N.,
BHATTACHARYA C. P.,
DASTIDAR SUJATA G.
Publication year - 1993
Publication title -
apmis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0903-4641
DOI - 10.1111/j.1699-0463.1993.tb00133.x
Subject(s) - antimycobacterial , streptomycin , in vitro , phenothiazine , rifampicin , in vivo , chemistry , isoniazid , mycobacterium tuberculosis , pharmacology , stereochemistry , microbiology and biotechnology , antibiotics , biology , tuberculosis , biochemistry , medicine , pathology
Methdilazine (Md) could inhibit various Mycobacterium spp. at 5–15 μg/ml concentrations in vitro as well as in vivo . When Md was tested in combination with streptomycin (Sm), rifampicin (Rf) or methyl‐DOPA (m‐D), it showed synergistic effects only with respect to methyl‐DOPA.