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Intracellular levels and extracellular release of lysosomal enzymes from peripheral blood monocytes in pulmonary tuberculosis patients
Author(s) -
JASWAL S.,
DHAND R.,
SETHI A. K.,
KOHLI K. K.,
GANGULY N. K.
Publication year - 1993
Publication title -
apmis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0903-4641
DOI - 10.1111/j.1699-0463.1993.tb00080.x
Subject(s) - intracellular , extracellular , peripheral blood , basal (medicine) , pulmonary tuberculosis , enzyme , medicine , tuberculosis , immunology , peripheral , long term potentiation , endocrinology , pathology , biology , biochemistry , insulin , receptor
The intracellular activity and extracellular release (basal and latex‐stimulated) of B‐glucuronidase (BG) and N‐acetylglucosaminidase (NAG), measured fluorimetrically, were observed to be significantly (P<0.05) higher in blood monocytes (BM) of untreated pulmonary tuberculosis (TB) patients compared to those of age‐ and sex‐matched controls and Mantoux‐positive subjects without any evidence of active disease. After completion of antituberculous therapy, BG and NAG activities declined appreciably (P<0.05) and their levels became comparable to those in control subjects. The present results suggest the potentiation of the oxygen‐independent defense mechanism of BM in pulmonary TB.