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Macrophage association of polyomavirus in progressive multifocal leukoencephalopathy: an immunohistochemical and ultrastructural study
Author(s) -
MESQUITA ROBERTO,
PARRAVICINI CARLO,
BJÖRKHOLM MAGNUS,
EKMAN MARIANNE,
BIBERFELD PETER
Publication year - 1992
Publication title -
apmis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0903-4641
DOI - 10.1111/j.1699-0463.1992.tb04031.x
Subject(s) - progressive multifocal leukoencephalopathy , vacuole , pathology , immunohistochemistry , pathogenesis , ultrastructure , phagocytosis , jc virus , macrophage , lymphoma , medicine , virus , biology , virology , immunology , in vitro , cytoplasm , biochemistry
Progressive multifocal leukoencephalopathy (PML) in a patient following autologous bone marrow transplantation for a non‐Hodgkin's centroblastic lymphoma was studied by immunohistochemistry and transmission electron microscopy. Our observations indicate that a large amount of polyomavirus, most probably JC virus, is taken up and segregated within vacuoles of macrophages by phagocytosis. A relevant role of macrophages in the pathogenesis of PML is emphasized.