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Influence of muramyl dipeptide on renal candidiasis in genetically distinct mice
Author(s) -
MARQUIS GABRIEL A.,
BOUSHIRA MICHELE,
RUSSO PIERRE,
MONTPLAISIR SERGE
Publication year - 1992
Publication title -
apmis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0903-4641
DOI - 10.1111/j.1699-0463.1992.tb04027.x
Subject(s) - candida albicans , muramyl dipeptide , kidney , ratón , corpus albicans , medicine , incidence (geometry) , colony forming unit , inflammation , immunology , biology , microbiology and biotechnology , bacteria , immune system , physics , genetics , optics
Susceptible (DBA/2) and resistant (C57BL/6) mice were inoculated intravenously with Candida albicans to evaluate the effect of a four‐day prophylaxis with muramyl dipeptide (MDP) on the renal burden of organisms during the first week after infection. In sham‐treated DBA/2 mice injected with 8 times 10 4 candida cells, renal CFU (LOG 10 , ± SEM) on days 1, 4 and 7 after infection were found to average 5.050 ± 0.109, 4.882 ± 0.133 and 5.482 ± 0.245. In sham‐treated C57BL/6 mice injected with 2 times 10 5 candida cells, renal CFU on days 1, 4 and 7 reached only 3.610 ± 0.118, 3.404 ± 0.107 and 4.176 ± 0.580. MDP‐treated DBA/2 mice achieved significant reduction in CFU of C. albicans on day 1 (1.3 log units) and day 4 (0.6 log unit), while MDP‐treated C57BL/6 mice had significant reduction in CFU of C. albicans only on day 1 (0.6 log unit) after infection. Sham‐treated mice of both strains had a 28.6 to 30% increase in kidney weights on day 4 only, a transient change not seen in MDP‐treated mice. Histopathological examination on days 8, 15 and 21 after infection revealed a higher incidence of renal papillary necrosis in DBA/2 mice than C57BL/6 mice (approximately 70% vs 10%). The incidence of granulomas and of chronic interstitial inflammation was much higher in MDP‐treated mice. We conclude that the genetic makeup of the host influences the potential effectiveness of MDP as a biological response modifier.