Premium
Interferon‐gamma may enhance infection of blood‐derived macrophages with HTV‐1 in the presence of HIV‐positive serum
Author(s) -
DEGRÉ MIKLOS,
BECK SOLVEIG,
ROLLAG HALVOR
Publication year - 1992
Publication title -
apmis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0903-4641
DOI - 10.1111/j.1699-0463.1992.tb00898.x
Subject(s) - antibody , receptor , human immunodeficiency virus (hiv) , interferon , virus , interferon gamma , virology , macrophage , immunology , biology , chemistry , cytokine , microbiology and biotechnology , in vitro , biochemistry
HIV multiplication in blood‐derived macrophages was slightly inhibited by pretreatment of cells with interferon‐gamma or by preincubation of virus with serum containing antibodies against HIV. When these pretreatments were combined, the HIV titres observed a short time after infection were enhanced. This effect was blocked by antibodies against Fc receptors but not by antibodies against CD4 receptors. Interferon enhanced the expression of Fc receptors on macrophages. The results indicate that IFN‐γ, in appropriate combinations with HIV‐antibody‐containing human serum, may enhance the rate of HIV infection of macrophages.