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Immunohistochemical characterization of an amphicrine mucinous islet‐cell carcinoma of the pancreas
Author(s) -
LAINE VELI J. O.,
EKFORS TAUNO O.,
GULLICHSEN RISTO,
NEVALAINEN TIMO J.
Publication year - 1992
Publication title -
apmis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0903-4641
DOI - 10.1111/j.1699-0463.1992.tb00880.x
Subject(s) - pathology , pancreas , biology , immunohistochemistry , medicine , endocrinology
Immunohistochemical characteristics of a mucinous islet‐cell carcinoma of the pancreas are described. The tumour presented with jaundice in a 59‐year‐old male. It consisted of polygonal atypical cells forming a reticular pattern, and invaded the common bile duct. In DNA flow cytometry, the tumour cells showed a clear‐cut aneuploid peak. Intercellular mucin was abundant. A panel of antisera and monoclonal markers was applied in the immunohistochemical analysis. In addition to general epithelial and endocrine markers, the tumour cells showed a focal positive immunoreaction with anti‐glucagon, anti‐insulin, anti‐vasoactive intestinal polypeptide, anti‐pancreatic secretory trypsin inhibitor and antiphospholipase A 2 antigen. At the ultrastructural level, mucous and neuroendocrine granules were demonstrated in the same tumour cells.