Premium
Leukaemia and anaemia in AKR/O mice
Author(s) -
HELLEBOSTAD MARIT,
ØSTBYE KIRSTEN M.,
HALVORSEN SVERRE
Publication year - 1992
Publication title -
apmis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0903-4641
DOI - 10.1111/j.1699-0463.1992.tb00859.x
Subject(s) - biology , medicine
In order to study the role of the spleen in erythropoiesis during AKR/O leukaemogenesis, we have cultured bone marrow and spleen erythroid colony‐forming units (CFU‐E) and burst‐forming units (BFU‐E) from AKR/O mice (n = 40) with leukaemia of varying severity and type of manifestation. Mice with leukaemia/lymphoma had reduced concentrations of bone marrow CFU‐E and BFU‐E as compared to healthy, age‐matched AKR/O mice. The spleen content of CFU‐E was increased, and highest in mice with a spleen size between 500 and 1000 mg. The largest spleens had a somewhat lower CFU‐E content. Mice with the highest spleen CFU‐E content most often had a normal PCV; however, 4/7 had a normal bone marrow CFU‐E concentration. During AKR/O leukaemogenesis with development of spleen enlargement, the spleen may act as an erythropoietic organ, and contribute to maintaining a normal PCV. This may be a temporary ability which is reduced or lost with further progress of the disease.