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Carcinoma in situ , gonadoblastoma, and early invasive neoplasia in a nine‐year‐old girl with 46, XY gonadal dysgenesis
Author(s) -
MÜLLER JØRN,
VISFELDT JAKOB,
PHILIP JOHN,
SKAKKEBÆK NIELS E.
Publication year - 1992
Publication title -
apmis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0903-4641
DOI - 10.1111/j.1699-0463.1992.tb00857.x
Subject(s) - gonadoblastoma , gonad , gonadal dysgenesis , carcinoma in situ , dysgerminoma , girl , biology , germ cell tumors , pathology , immunohistochemistry , germ cell , dysgenesis , carcinoma , medicine , anatomy , endocrinology , ovary , karyotype , genetics , chemotherapy , gene , chromosome
Carcinoma in situ (CIS), gonadoblastoma, and early invasive neoplasia were detected in the dysgenetic gonad of a nine‐year‐old girl with 46, XY gonadal dysgenesis. A close relationship between the three neoplastic components was supported by morphological and immunohistochemical studies. Our findings support the hypothesis that all germ cell tumours, including gonadoblastomas, originate from CIS germ cells formed during early embryonic life.