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The glomerular peripolar cell ‐ an immunohistochemical study
Author(s) -
GARDINER D. S.,
LINDOP G. B. M.
Publication year - 1992
Publication title -
apmis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0903-4641
DOI - 10.1111/j.1699-0463.1992.tb00847.x
Subject(s) - immunohistochemistry , cytoplasm , antiserum , vimentin , juxtaglomerular apparatus , pathology , biology , monoclonal antibody , cell type , antibody , cell , microbiology and biotechnology , immunology , endocrinology , medicine , renin–angiotensin system , biochemistry , blood pressure
The peripolar cell is a recently described glomerular epithelial cell which may be a new secretory component of the juxtaglomerular apparatus (JGA). The purposes of this study were to identify immunohistochemical markers specific for peripolar cells and to elucidate the composition of their cytoplasmic granules. We examined tissue from normal human and sheep kidneys with a variety of monoclonal antibodies and antisera. A minority of peripolar cells showed immunoreactivity for vimentin but no other intermediate filament. Neuroendocrine markers were negative. The granules of peripolar cells contain a variety of plasma proteins with the exception of IgM. It is likely that peripolar cells absorb plasma proteins from the glomerular filtrate. The reason for this is uncertain; however, their unique position at the vascular pole of normal kidneys suggests a specialized function.