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Mechanism of aminoglycoside resistance in Danish Staphvlococcus aureus strains during the years 1979–1987
Author(s) -
MADSEN OLE RINTEK,
LORENTZEN JAN SØBO,
FRIMODTMØLLER NIELS,
MORTENSEN IDA,
ROSDAHL VIBEKE THAMDRUP
Publication year - 1991
Publication title -
apmis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0903-4641
DOI - 10.1111/j.1699-0463.1991.tb05187.x
Subject(s) - aminoglycoside , danish , microbiology and biotechnology , mechanism (biology) , staphylococcus aureus , biology , antibiotics , bacteria , genetics , physics , philosophy , linguistics , quantum mechanics
A total of 49 gentamicin‐resistant strains of Staphylococcus aureus isolated from blood (n = 26) or from other sites (n = 23) during the years 1979 to 1987 were evaluated for the presence of aminoglycoside‐inactivating enzymes on the basis of minimum inhibitory concentrations measured by agar dilution as well as inhibition zone diameters determined by disc diffusion. Enzymatic activity was caused by AAC (6′)III/APH (2″) in 45 strains, and by AAC (6′)III/APH (2″)+APH (3′) in four strains. No changes in the distribution of enzymatic activity were observed during the eight years.