Premium
Properties of a deep Proteus R mutant isolated from clinical material
Author(s) -
KRAJEWSKAPIETRASIK DANUTA,
RÓZALSKI ANTONI,
BARTODZIEJSKA BEATA,
RADZIEJEWSKALEBRECHT JOANNA,
MAYER HUBERT,
KOTELKO KRYSTYNA
Publication year - 1991
Publication title -
apmis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0903-4641
DOI - 10.1111/j.1699-0463.1991.tb05182.x
Subject(s) - proteus mirabilis , mutant , proteus , chemotype , microbiology and biotechnology , biology , chemistry , gene , escherichia coli , genetics , botany , essential oil
Some biological features of a deep P. mirabilis 17301 R mutant isolated from the urine of a patient with chronic UTI were studied and compared with similar features of P. mirabilis S forms and five induced Proteus R mutants of different chemotypes. There were no differences in lethal toxicity and adhesion to human uroepithelial cells. Of all the R mutants tested, two of them, 17301 and R4, exhibited strong cell‐bound hemolytic activity. The P. mirabilis R 17301 was characterized as the most invasive (tested in L929 mouse fibroblasts) compared to the other Proteus S and R forms. The structure of PS from a clinical R mutant investigated and the results of serological studies prove that this mutant belongs to the Rc chemotype.