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Effect of interferon treatment on expression of gC and gE glycoproteins in herpes simplex virus‐infected cells
Author(s) -
HOLBERGPETERSEN MONA,
BÖHMER ELLEN,
NAMORK ELLEN,
DEGRE MIKLOS
Publication year - 1991
Publication title -
apmis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0903-4641
DOI - 10.1111/j.1699-0463.1991.tb05154.x
Subject(s) - virology , herpes simplex virus , glycoprotein , interferon , virus , simplexvirus , biology , microbiology and biotechnology , herpesviridae , viral disease
The effect of interferon treatment on the herpes simplex virus type 1 (HSV‐1)‐specific glycoproteins gC and gE in homologous and heterologous cells has been investigated. In human embryonic fibroblastic cells, human leukocyte interferon inhibited virus multiplication and expression of the HSV‐1‐specific glycoproteins gC and gE on the cell surface in a dose‐dependent manner. In heterologous baby hamster kidney cells, the human interferon had no effect on virus multiplication. However, the surface expression of the HSV‐1‐specific glycoproteins was reduced, as shown by erythrocyte rosette formation, by attachment of monodisperse polystyrene particles coated with antibodies and by immunogold scanning electron microscopy.