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Frequency of SV40‐specific cytotoxic T‐lymphocyte precursors in two SV40 T‐antigen transgenic mouse lines
Author(s) -
JURETIC ANTONIO,
KNOWLES BARBARA B.
Publication year - 1991
Publication title -
apmis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0903-4641
DOI - 10.1111/j.1699-0463.1991.tb05141.x
Subject(s) - ctl* , cytotoxic t cell , antigen , sv40 large t antigen , virology , t lymphocyte , transgene , biology , genetically modified mouse , microbiology and biotechnology , immunology , cell culture , in vitro , cd8 , transfection , gene , genetics
Cytotoxic T‐lymphocyte precursors (CTL‐P) from control C57BL/6 mice and from mice of two simian virus 40 (SV40) T‐antigen transgenic lines, 427 and 419, specifically nonresponsive and responsive, respectively, to SV40 T antigen, were quantitated by limiting dilution (LD) after immunization with SV40. CTL‐P frequencies for the SV40 T antigen‐responsive 419 line transgenic mice were within the range established in C57BL/6 mice, whereas no CTL‐P could be demonstrated for the SV40 T antigen‐tolerant 427 line mice. These results suggest that deletion or anergy of SV40 T antigen‐responsive clones underlies the specific profound tolerance of 427 line mice.