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Generation of reactive oxygen species by blood monocytes in human Plasmodium falciparum and P. vivax infections
Author(s) -
DUBEY M. L.,
RAI S. K.,
GANGULY N. K.,
KALRA A.,
VARMA S. C.,
MAHAJAN R. C.
Publication year - 1991
Publication title -
apmis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0903-4641
DOI - 10.1111/j.1699-0463.1991.tb05140.x
Subject(s) - immunosuppression , plasmodium falciparum , immunology , chemiluminescence , malaria , plasmodium vivax , medicine , reactive oxygen species , biology , chemistry , biochemistry , organic chemistry
Generation of reactive oxygen radicals by peripheral blood monocytes was measured by luminol‐dependent chemiluminescence in 23 P. vivax ‐ and 7 P. falciparum ‐infected patients. The chemiluminescence index (CLI) was not found to be significantly higher in P. vivax ‐infected cases than in healthy controls. But in patients with P. falciparum infection, the CLI was significantly higher compared to controls as well as to P. vivax ‐infected patients. In two severe and complicated P. falciparum ‐infected cases, CLI was found to be higher than in mild cases. As immunosuppression is more marked in falciparum malaria than in vivax cases, the role of oxygen radical generation in immunopathology and causation of immunosuppression in falciparum malaria needs further investigation.