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Hypersensitivity of delayed type in hypertensive patients
Author(s) -
OLSEN FINN
Publication year - 1991
Publication title -
apmis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0903-4641
DOI - 10.1111/j.1699-0463.1991.tb05119.x
Subject(s) - medicine , antigen , delayed hypersensitivity , agarose , immunology , autoimmunity , antibody , biology , biochemistry
The agarose migration technique was used for demonstration of delayed‐type hypersensitivity to arterial vessel wall antigens in patients suffering from chronic essential hypertension. By means of this technique, it was demonstrated that the migration indices from the hypertensive patients differed significantly from the normotensive control persons, P < 0.005. The significant difference was abolished when anti‐LIF was added to the migration tests. This means that a hypersensitivity of the delayed type had developed in the hypertensive patients and the results indicated that the hypersensitivity was an autoimmunity to arterial vessel wall antigens.