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Characteristics of spontaneously agglutinating Proteus mirabilis strains from bacteriuric patients
Author(s) -
KrajewskaPietrasik DANUTA,
Larsson PETER,
Zych KRYSTYNA,
Wlodarczyk JANUSZ,
Gromska WIESLAWA
Publication year - 1991
Publication title -
apmis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0903-4641
DOI - 10.1111/j.1699-0463.1991.tb01283.x
Subject(s) - proteus mirabilis , proteus , microbiology and biotechnology , chemistry , medicine , biology , bacteria , escherichia coli , genetics , biochemistry , gene , staphylococcus aureus
Out of 210 Proteus mirabilis isolates from bacteriuric patients a total of eight spontaneously agglutinating strains were found. SDS‐PAGE analysis of their lipopolysaccharides (LPS), the separation of polysaccharide fractions (PS) by gel filtration, and chemical characterization of PSs were performed. Out of the eight strains one S form and one mutant classified as Rc were detected. The remaining six strains were recognized as Ra and intermediate forms. When tested in a hematogenous infection model in mice, the P. mirabilis Rc mutant survived in kidneys for at least two weeks, while the Re mutant used as control was eliminated within 20 h after the challenge. These data indicated that strains of P. mirabilis may be pathogenic even if they express very incomplete LPS.