Premium
The antibacterial activity of a siderophore
Author(s) -
Hartzen SUSANNE HARTVIG,
FrimodtMØLler NIELS,
Thomsen VILLY FRØLUND
Publication year - 1991
Publication title -
apmis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0903-4641
DOI - 10.1111/j.1699-0463.1991.tb01274.x
Subject(s) - cefotaxime , fusidic acid , gentamicin , microbiology and biotechnology , vancomycin , chemistry , ascorbic acid , staphylococcus aureus , antibiotics , antibacterial agent , antimicrobial , biology , bacteria , genetics , food science
The in vitro activity of deferoxamine (DFO) combined with cephalothin, gentamicin, cefotaxime, vancomycin, and fusidic acid, in the presence or absence of the reductant ascorbic acid (AA) was investigated against Staphylococcus aureus by a macrobroth dilution technique and killing curve kinetics. DFO and in particular DFO + AA lowered the MICs of cephalothin, gentamicin, cefotaxime, and fusidic acid for most of the strains and in some instances also the MICs of vancomycin. To characterize the interaction between DFO or DFO + AA and antimicrobials we applied the growth constants of logarithmic growth phase. Generally DFO acted synergistically with cephalothin, gentamicin, vancomycin, and fusidic acid, particularly in the presence of AA, and in some cases synergy was demonstrated with cefotaxime, too.