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Experimental candidosis in pregnant mice
Author(s) -
Jensen H. E.,
Hau J.,
AalbæK B.,
SchØNheyder H.
Publication year - 1991
Publication title -
apmis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0903-4641
DOI - 10.1111/j.1699-0463.1991.tb01267.x
Subject(s) - candida albicans , aspergillus fumigatus , histopathology , hypha , placenta , microbiology and biotechnology , biology , corpus albicans , andrology , mycosis , pregnancy , fetus , pathology , immunology , medicine , genetics
Pregnant mice were challenged intravenously with doses of 1 × 10 3 ‐ 1 × 10 7 Candida albicans blastospores, and from postmortem histopathology it was found that C. albicans had a propensity for localization in the murine placenta. At the highest dose, blastospores, hyphae and pseudohyphae were randomly located in the foeto‐placental units, whereas proliferation of fungi at lower doses started in the rim of the placental disc, after which it spread along Reichert's membrane and/or the splanchnopleure, eventually attacking the foetal skin. These findings are analogous to our previous observations on the nature of Aspergillus fumigatus infection in pregnant mice.