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Omental dendritic cells: la expression and relation to macrophages
Author(s) -
Holub MIROSLAV,
VĚTviČKa VÁCLAV,
ŘIha IVAN,
SvobodovÁ JANA,
MohelskÁ HANA
Publication year - 1990
Publication title -
apmis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0903-4641
DOI - 10.1111/j.1699-0463.1990.tb05042.x
Subject(s) - immune system , biology , acid phosphatase , antigen , stimulation , microbiology and biotechnology , immunology , chemistry , enzyme , endocrinology , biochemistry
Rat omental dendritic cells (ODC) occur in two forms, mainly spindle‐shaped, la“, on the surface, and stellar, Ia + within the omentum. Like macrophages, most ODC label with W3/25 mAb and have a demonstrable activity of non‐specific esterase, acid phosphatase and ATPase. Up to 30% of ODC are actively phagocytic. The proportion of Ia + ODC rises 7 days after ip antigenic stimulation and there seems to be a reciprocal development of la positivity and phagocytic capacity between ODC and macrophages 3 and 5 days after ip immunization. ODC contribute to the overall fluctuation of la expression in the entire omentum after immunization. Ia + ODC display a linear arrangement along prelymphatic spaces and may be related to the formation of new lymph vessels. They also constitute the stroma of pseudofollicles containing clusters of what are presumably T‐helper lymphocytes closely attached to ODC, scattered suppressor T lymphocytes and B cells accumulating in later stages at the immune response.