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Quartz‐induced production of reactive oxygen metabolites by activated human monocyte‐derived macrophages
Author(s) -
Nyberg PETER,
Klockars MATTI
Publication year - 1990
Publication title -
apmis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0903-4641
DOI - 10.1111/j.1699-0463.1990.tb05002.x
Subject(s) - macrophage , reactive oxygen species , monocyte , silicosis , lucigenin , lipopolysaccharide , chemistry , chemiluminescence , immune system , quartz , macrophage activating factor , microbiology and biotechnology , immunology , biology , biochemistry , medicine , in vitro , pathology , superoxide , chromatography , enzyme , paleontology
Quartz but not titanium dioxide (TiO 2 ) induced the production of reactive oxygen metabolites (ROM) by human monocyte‐derived macrophages, as measured by lucigenin dependent chemiluminescence. Activation of the macrophages with BCG, bacterial lipopolysaccharide (LPS), and macrophage‐activating factor (MAF) caused a prominent increase of quartz‐induced ROM production, MAF having the strongest effect. The activation did not affect the TiO 2 responses to the same extent. Assuming that ROM have a role in the pathogenesis of silica‐induced disease in man, we suggest that enhancement of quartz‐induced production of ROM by activated pulmonary macrophages may at least partly explain the experimental and epidemiological data indicating that activation of the immune system during infection promotes the development of silicosis.