Premium
In vitro activity of 9 antimicrobial agents against 177 strains of Haemophilus influenzae isolated from hospitalized patients
Author(s) -
Teigen KJELL,
Lingaas EGIL
Publication year - 1990
Publication title -
apmis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0903-4641
DOI - 10.1111/j.1699-0463.1990.tb04996.x
Subject(s) - haemophilus influenzae , antimicrobial , microbiology and biotechnology , in vitro , medicine , haemophilus , biology , antibiotics , bacteria , genetics
In vitro activity of 4 commonly used and 5 new antibiotics was examined against 177 strains of Haemophilus influenzae. All strains were collected from various sites in patients with clinical infections. The study confirms that several newer antibiotics are useful alternatives to older drugs, as measured by in vitro activity. Ciprofloxacin and ofloxacin were the most active agents, (MIC 90 0.012 μg/ml and 0.05 μg/ml respectively), followed by aztrreonam (MIC 90 0.1 μg/ml) and cefuroxime (MIC 90 0.8 μg/ml). A new macrolide, azithromycin (CP 62,993), was more active than erythromycin, MIC 90 1.6 μg/ml vs 6.4 μg/ml. Beta‐lacta‐mase production was detected in 4.5% (8/177) of the strains. In vitro activity was the same against strains collected in 1985 and 1988. No increase in beta‐lactamase production was recorded.