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Toxicity of, and histological lesions caused by, ribosome‐inactivating proteins, their IgG‐conjugates, and their homopolymers
Author(s) -
Battelli MARIA GIULIA,
Barbieri LUIGI,
Stirpe FIORENZO
Publication year - 1990
Publication title -
apmis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0903-4641
DOI - 10.1111/j.1699-0463.1990.tb04975.x
Subject(s) - ribosome inactivating protein , saporin , toxicity , ribosome , protein biosynthesis , chemistry , biochemistry , biology , cytotoxicity , rna , microbiology and biotechnology , in vitro , immunotoxin , organic chemistry , gene
The toxicity of, and the lesions brought about by, several ribosome‐inactivating proteins (bryodin, gelonin, momordin, pokeweed antiviral protein from seeds, saporin 6, trichokirin and momorcochin‐S), either native, or conjugated to bovine IgG, or polymerized, were studied in the mouse. Severe necrotic liver damage was the main lesion present in animals receiving lethal doses of the proteins. The toxicity of ribosome‐inactivating proteins increased after conjugation to IgG or homopolymerization. The toxicity of conjugates to mouse was not predictable from the inhibitory activity on cell‐free protein synthesis.