Premium
Distribution in tissue sections of the human groEL stress‐protein homologue
Author(s) -
Evans D. J.,
Norton P.,
Ivanyi J.
Publication year - 1990
Publication title -
apmis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0903-4641
DOI - 10.1111/j.1699-0463.1990.tb01055.x
Subject(s) - groel , distribution (mathematics) , chemistry , biology , biochemistry , gene , escherichia coli , mathematics , mathematical analysis
A monoclonal antibody (ML30) raised against the 65 kDa heat‐shock protein of mycobacteria showed widespread staining of sections from standard paraffin‐embedded human tissues. The staining had a granular pattern and was particularly marked in cells with abundant mitochondria. Increased staining was observed in the synovial lining, histocytes and in the endothelium of reactive and rheumatoid synovium; it was also increased in the reactive lung alveolar lining. It is suggested that the antibody identifies an epitope in mitochondria of a protein homologous with the groEL heat‐shock protein of bacteria.