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The influence of a histamine 2 ‐receptor antagonist on the healing of an experimentally induced gastric mucosal lesion
Author(s) -
Park PEROLA,
Alumets JAN,
Arvidsson STEFAN,
Grimelius LARS,
Haglund ULF
Publication year - 1990
Publication title -
apmis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0903-4641
DOI - 10.1111/j.1699-0463.1990.tb01037.x
Subject(s) - ranitidine , hydroxyproline , lesion , wound healing , saline , antagonist , medicine , receptor antagonist , pathology , histamine h2 receptor , receptor , surgery
The effect of an H 2 ‐receptor antagonist (ranitidine) on the healing of gastric mucosal lesions was studied. Mucosal lesions were induced by a standardized thermo‐mechanical technique. The healing process was assessed by macro‐ and light microscopical examination. It was further evaluated by measurements of the tissue contents of hydroxyproline, a chemical compound reflecting collagen, and of DNA and RNA, reflecting cell frequency and protein synthesis respectively, in the gastric wall from both injured and wound‐free areas. The healing process was more rapid in ranitidine‐treated animals than in controls. After four weeks, however, the lesion in nine out of ten animals had healed in the ranitidine‐treated group and seven of nine rats in the control group. At that time the amounts of hydroxyproline, DNA and RNA did not differ between the two groups. These findings may be taken as an indication that the tissue components of the healed lesions were similar in ranitidine‐treated rats and in the saline controls, i.e. the different speeds of the healing process did not seem to influence the components of the scar tissue.