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Inhibition of the bacteriolytic effect of β‐lactam‐antibiotics on Staphylococcus aureus by the polyanionic drugs suramin and Evans Blue *
Author(s) -
Wecke JÖRG,
Franz MARITA,
Giesbrecht PETER
Publication year - 1990
Publication title -
apmis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0903-4641
DOI - 10.1111/j.1699-0463.1990.tb01004.x
Subject(s) - autolysis (biology) , suramin , evans blue , chemistry , antibiotics , lactam , microbiology and biotechnology , bacteria , pharmacology , biochemistry , biology , stereochemistry , enzyme , in vitro , genetics , endocrinology
The anionic polyelectrolytes suramin and Evans Blue inhibited different autolytic systems involved in wall growth and wall turnover of growing staphylococci and in wall autolysis of resting bacteria. Moreover, both substances lowered the β‐lactam‐induced pre‐lytic release of cytoplasmic constituents from staphylococci, and inhibited the β‐lactam‐induced bacteriolysis as well as the loss of viability. The protective effects of these sulfonated drugs against bacteriolysis were also monitored by electron microscopy. Some medical implications of our results are discussed.