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Dysfunction of the mononuclear phagocytic system in sepsis
Author(s) -
GUTIÉRREZFERNÅNDEZ J.,
MAROTO M. C.,
PIÉDROLA G.,
ZAMORA E.
Publication year - 1989
Publication title -
apmis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0903-4641
DOI - 10.1111/j.1699-0463.1989.tb00813.x
Subject(s) - sepsis , phagocytosis , septic shock , immune system , receptor , immunology , medicine , shock (circulatory) , nephelometry , peripheral blood mononuclear cell , fc receptor , biology , antibody , in vitro , biochemistry
An in vivo study has been undertaken of the Fc(lgG) receptor‐mediated phagocytic capacity of macrophages (clearance of anti‐rhesus D‐coated‐ 51 Cr‐labelled autologous erythrocytes, expressed as half‐lives) in 15 cases of sepsis to establish its behaviour and correlate this function to levels of circulating immune complexes (anti‐Clq‐nephelometry). Five patients with low activity (2261 ± 859 minutes) developed septic shock; the other ten showed high activity (5.8 ± 1.5 minutes) and did not develop septic shock. Differences from the control group (30 ± 12 minutes) were found (p < 0.001). Receptor activity was related to the presence of circulating immune complexes (p ± 0.001; δ= 0.862) but not to age, sex, or the presence/absence of splenomegaly during the illness. Eight patients responded favourably; seven patients died; but the receptor activity was not related to this. During sepsis it is possible to find higher Fc(IgG) receptor‐mediated phagocytic capacity of macrophages. Excessive formation of circulating immune complexes has a negative influence on Fc(IgG) receptor‐mediated phagocytosis. This activity of macrophages, measured at the start of the sepsis, was not associated with the final outcome of the patients' illness (cure or death).