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Mechanism of spontaneous loss of heat‐stable toxin (STa) production in enterotoxigenic Escherichia coli
Author(s) -
SOMMERFELT HALVOR,
HAUKANES BJØRNIVAR,
KALLAND KARL HENNING,
SVENNERHOLM ANNMARI,
SANCHÉZ JOAQUIN,
BJORVATN BJARNE
Publication year - 1989
Publication title -
apmis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0903-4641
DOI - 10.1111/j.1699-0463.1989.tb00812.x
Subject(s) - enterotoxigenic escherichia coli , enterotoxin , heat stable enterotoxin , escherichia coli , plasmid , microbiology and biotechnology , toxin , southern blot , biology , gene , genetics
Five strains of enterotoxigenic Escherichia coli (ETEC) showing spontaneous loss of heat‐stable enterotoxin (STa) production were studied to elucidate the underlying genetic mechanisms. Southern blot analysis revealed that loss of STa production, and the corresponding lack of hybridization with the STa gene probes, were associated with deletions of DNA fragments harboring the relevant toxin genes rather than with loss of plasmids.