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Rheumatoid arthritis cells and biochemical changes in turpentine‐induced pleuritis in rabbits
Author(s) -
FAURSCHOU P.,
GRUNNET N.,
WINDING O.,
DIRKSEN A.,
FAARUP P.
Publication year - 1989
Publication title -
apmis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0903-4641
DOI - 10.1111/j.1699-0463.1989.tb00808.x
Subject(s) - turpentine , rheumatoid arthritis , lactic dehydrogenase , pleural effusion , medicine , pleurisy , pleural fluid , pleural cavity , arthritis , effusion , pathology , immunology , enzyme , chemistry , biochemistry , surgery
When turpentine was instilled into the right pleural cavity in rabbits a pleural effusion developed in half of the animals, with a low pH, low glucose concentration, high lactic dehydrogenase activity and the constant presence of rheumatoid arthritis cells in the affected pleural cavity. The biochemical values in the pleural fluid were significantly different from the values for normal pleural fluid obtained by a special microtechnique. These changes resulting from the experimentally induced, simple, irritative turpentine pleuritis are similar to the findings in the pleural effusion in human rheumatoid pleuritis; this implies that such changes are probably non‐specific and without evidence of an immunological background.