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The in vitro activity of norfloxacin, ofloxacin and ciprofloxacin and other antibiotics in current use against Neisseria gonorrhoeae
Author(s) -
MELBY KJETIL,
FÆGRI AGNETE
Publication year - 1989
Publication title -
apmis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0903-4641
DOI - 10.1111/j.1699-0463.1989.tb00798.x
Subject(s) - neisseria gonorrhoeae , norfloxacin , ofloxacin , ciprofloxacin , microbiology and biotechnology , ampicillin , cefotaxime , antibiotics , agar dilution , penicillin , beta lactamase , antibacterial agent , chemistry , biology , minimum inhibitory concentration , escherichia coli , biochemistry , gene
One hundred non‐beta‐lactamase‐producing and 50 beta‐lactamase‐producing strains of Neisseria gonorrhoeae serogroup WI and WII/III were tested in vitro by an agar dilution method against a panel of antibiotics including ciprofloxacin, ofloxacin and norfloxacin. All strains irrespective of beta‐lactamase production and serogroup allocation, were inhibited by 0.125 mg/l of all quinolones. Ciprofloxacin turned out to be most active followed by ofloxacin and norfloxacin. All strains were also inhibited by low concentrations of cefotaxime (MIC <0.25 mg/l). Many strains mostly among the beta‐lactamase‐producing strains were resistant (MIC > 4 mg/l) to doxycycline. Ampicillin is still active against the majority of non‐beta‐lactamase‐producing strains. The majority of the strains belonged to serogroup WII/III which are known to be less sensitive to penicillin G and ampicillin.