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Tissue sampling and histological grading in colorectal cancer
Author(s) -
HALVORSEN TORE B.
Publication year - 1989
Publication title -
apmis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0903-4641
DOI - 10.1111/j.1699-0463.1989.tb00786.x
Subject(s) - grading (engineering) , pathology , medicine , colorectal cancer , adenocarcinoma , sampling (signal processing) , cancer , biology , filter (signal processing) , ecology , computer science , computer vision
Microscopical sections from 50 colorectal adenocarcinomas were examined to test the representativity of routine sections with regard to histological grade. Point‐counting of drawings of microscopical fields from randomly selected parts of whole‐tumour specimens formed the basis for estimates of volumetric relationships between parts of the tumours exhibiting well, moderately and poorly differentiated glands. An overall histological grade was assigned to each tumour, and was compared with the grade obtained by examining a limited number of routine sections from the same tumour. It is concluded that if superficial and deep parts of the tumours are included, and provided that the sections measure at least 2–3 cm, colorectal adenocarcinomas may be graded with sufficient accuracy on the basis of one or two routine sections.