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Further studies on post‐antibiotic effect and synergism in two strains of Streptococcus faecalis
Author(s) -
FUURSTED K.
Publication year - 1989
Publication title -
apmis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0903-4641
DOI - 10.1111/j.1699-0463.1989.tb00751.x
Subject(s) - aminoglycoside , streptomycin , antibiotics , ampicillin , microbiology and biotechnology , enterococcus faecalis , streptococcus , strain (injury) , chemistry , biology , bacteria , staphylococcus aureus , genetics , anatomy
The differences in the synergistic potential for either killing effect or increase in duration of post‐antibiotic effect (PAE) seen with various beta‐lactam‐aminoglycoside combinations in two strains of Streptococcus faecalis were further studied to examine this relationship in more detail. It was seen that a strain which produced a synergistic increase in recovery period (PAE ≥ 0.5 h), comparing the beta‐lactam antibiotics alone and when combined with streptomycin, showed increased sensitivity (≥ 1 log 10 reduction in viable counts) to a subinhibitory concentration of streptomycin added to a culture recovering from the PAE; this was not demonstrated with a strain showing no increase in PAE when briefly exposed to a combination therapy, although its corresponding killing curve was clearly synergistic. Moreover, it was seen that the differences in the synergistic prolongation of recovery period when combining various aminoglycosides at 1/4 × MIC with ampicillin were consistent with the different duration of PAE with the particular aminoglycoside alone at the MIC.