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In vitro activity of vancomycin against enterococci
Author(s) -
POULSEN PATRICIA N.,
HARTZEN SUSANNE H.,
RASMUSEN HANNE
Publication year - 1989
Publication title -
apmis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0903-4641
DOI - 10.1111/j.1699-0463.1989.tb00495.x
Subject(s) - in vitro , vancomycin , microbiology and biotechnology , vancomycin resistant enterococci , enterococcus , biology , chemistry , medicine , antibiotics , bacteria , staphylococcus aureus , biochemistry , genetics
The in vitro activity of vancomycin against 40 clinical isolates of enterococci was determined by a macro‐tube dilution method and by quantitative killing curve procedures employing the standard medium of our department, i.e. a filtered ox broth. An attempt to remove the influence of technical factors on the MBC determination was made by using an inoculum in the early logarithmic growth phase and ensuring the exposure of all the organisms to the antibiotic. Vancomycin showed a good inhibitory activity for the enterococci tested (MIC 90 of 1.6 μg/ml, 3.1 μ/ml and 1.6 μg/ml for S. faecalis, S. faecium and S. durans , respectively), but no bactericidal effect could be demonstrated as measured by the MBCs (> 100 μg/ml) and killing curve procedures.