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Effect of PGE 2 and LTB 4 on vicia villosa binding lymphocytes
Author(s) -
GUALDE NORBERT,
COOK JEANNEMARIE,
GUIBERT FABIENNE
Publication year - 1988
Publication title -
apmis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0903-4641
DOI - 10.1111/j.1699-0463.1988.tb05340.x
Subject(s) - vicia villosa , splenocyte , villosa , biology , lymphocyte , concanavalin a , immunology , microbiology and biotechnology , in vitro , biochemistry , immune system , botany , ecology , cover crop
Since there is a good deal of evidence that vicia villosa lectin (VVA) binds to contrasuppressor cells, mouse splenocytes and thymocytes were sorted by binding to VVA‐coated Petri dishes. It was observed that vicia villosa adherent cells (VVA(+)) did not proliferate when mitogens were added to cultures, but they did enhance the thymidine uptake of PHA or ConA stimulated vicia villosa non‐adherent (VVA(‐)) splenocytes. PGE, treatment of VVA(+) splenocytes or VVA(+) immature thymocytes did not very much affect the VVA(+) cell behavior. On the other hand, LTB 4 increased the enhancing capability of VVA(+) splenocytes. Therefore, investigations dealing with the effects of LTB 4 on lymphocyte subsets which may include VVA(+) cells should take into consideration the possible presence of contrasuppressor cells.