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Human milk fat globule antigen III D 5, steroid receptors and histopathologic parameters in breast cancer
Author(s) -
HELLE MARKKU,
HELIN HEIKKI,
ANTONEN JAAKKO,
KROHN KAI
Publication year - 1988
Publication title -
apmis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0903-4641
DOI - 10.1111/j.1699-0463.1988.tb05324.x
Subject(s) - breast cancer , receptor , steroid , antigen , mammary gland , medicine , endocrinology , cancer , pathology , immunology , hormone
Immunohistochemical reactivity of mammary carcinomas with the monoclonal human milk fat globule (HMFG) antibody III D 5, and the estrogen receptor (ER) and progesterone receptor (PR) status were compared with the histopathology of primary breast cancer. The reactivity with HI D 5 has earlier been shown to be associated with the estrogen receptor status of tumours and with a favourable prognisis. The reactivity of tumours with III D 5, as well as the presence of ER and PR correlated significantly with the histological features of differentiation; histological grade, nuclear grade, tumour necrosis and lymphoid infiltration. Reactivity with III D 5 correlated with all these parameters, while the presence of ER did not correlate with the nuclear grade and that of PR correlated only with the nuclear grade and the lymphoid infiltration of tumours. Reactivity of III D 5 may thus have prognostic and therapeutic implications in the management of breast cancer.