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Synergistic effect of ampicillin or vancomycin in combination with decreasing concentrations of streptomycin against enterococci
Author(s) -
FUURSTED K.
Publication year - 1988
Publication title -
apmis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0903-4641
DOI - 10.1111/j.1699-0463.1988.tb05321.x
Subject(s) - streptomycin , ampicillin , enterococcus faecalis , vancomycin , antibiotics , microbiology and biotechnology , enterococcus faecium , chemistry , streptococcus , enterococcus , biology , bacteria , staphylococcus aureus , escherichia coli , biochemistry , genetics , gene
The extent of synergistic killing and duration of the post‐antibiotic effect (PAE) was evaluated in streptomycin‐susceptible strains of Streptococcus faecalis and Streptococcus faecium with 20 mcg/ml of ampicillin or 10 mcg/ml of vancomycin in combination with decreasing concentrations of streptomycin (20, 10, 5, 2, 1, 0.5 mcg/ml). The bactericidal activity or duration in recovery period declined progressively in a linear pattern with decreasing concentrations of streptomycin. One log 10 or greater reduction in viable counts was seen with streptomycin concentrations of 2 mcg/ml or higher with both ampicillin and vancomycin. A synergistic increase in revocery period (PAE ≥ 0.5h) of ampicillin or vancomycin was observed with concentrations of streptomycin in excess of 2 mcg/ml and 1 mcg/ml, respectively. These results suggest that lower dosage of streptomycin in the therapy of enterococcal infections will probably result in a higher relapse rate.