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Prognostic significance of differential cell counts in non‐Hodgkin's lymphomas
Author(s) -
SCHULTZ HENRIK B.,
ERSBØLL JENS,
HOUGAARD PHILIP
Publication year - 1988
Publication title -
apmis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0903-4641
DOI - 10.1111/j.1699-0463.1988.tb05317.x
Subject(s) - cytology , lymphoma , biopsy , pathology , differential diagnosis , follicular lymphoma , medicine , malignant lymphoma , working formulation , large cell , malignant cells , non hodgkin's lymphoma , cancer , adenocarcinoma
The use of differential counting on H & E stained sections is proposed as a simple means to define low grade malignant and high grade malignant cytologic categories in non‐Hodgkin's lymphomas. Differential counts were performed in lymphoma biopsies from 6 16 cases. In each biopsy we counted 100 lymphoma cells and classified each cell as belonging to a “small”, “medium‐sized”, or “large” cell type. The results indicate the presence of two prognostically distinct cytologic categories: a low grade and a high grade malignant. Lymphomas with less than 10%“large” cells represented low grade malignant cytology. Included in this category were also the, mainly follicular, lymphomas with more then 70%“medium‐sized” cells (up to about 25%“large” cells). In addition to the cytologic category, the architectural pattern is of major prognostic importance. We recommend the use of three prognostic categories in non‐Hodgkin's lymphomas: I) Favourable architecture + favourable cytology. II) Unfavourable architecture + favourable cytology. III) Unfavourable cytology.