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Studies on ampicillin resistance in Achromobacter xylosoxidans
Author(s) -
GAHRNHANSEN BENTE,
SIBONI KNUD
Publication year - 1988
Publication title -
apmis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0903-4641
DOI - 10.1111/j.1699-0463.1988.tb05288.x
Subject(s) - achromobacter xylosoxidans , ampicillin , microbiology and biotechnology , amp resistance , medicine , biology , antibiotics , bacteria , genetics
Population analyses of susceptibility to ampicillin in ampicillin‐susceptible and ampicillin‐resistant strains of Achromobacter xylosoxidans revealed the existence of ampicillin‐resistant subpopulations in ampicillin‐susceptible isolates. Bacteria resistant to a concentration four times the one that inhibited the majority population had a frequency of 10 ‐3 to 10 ‐4 . Strains isolated from aqueous environments are often found susceptible to ampicillin, while sporadic cases of infections with A. xylosoxidans are often caused by ampicillin‐resistant strains. We suggest that the isolation from clinical specimens of ampicillin‐susceptible strains, therefore, may be an indication of nosocomial infections due to recently contaminated aqueous solutions or medical equipment.